Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1902224..1902726 Replicon chromosome
Accession NZ_OX637961
Organism Escherichia coli O25b:H4-ST131 isolate 86

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QQG89_RS09055 Protein ID WP_000767822.1
Coordinates 1902472..1902726 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QQG89_RS09050 Protein ID WP_001259255.1
Coordinates 1902224..1902475 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG89_RS09025 (1897402) 1897402..1898469 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QQG89_RS09030 (1898469) 1898469..1899539 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QQG89_RS09035 (1899536) 1899536..1900840 - 1305 WP_001546022.1 histidinol dehydrogenase -
QQG89_RS09040 (1900846) 1900846..1901745 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QQG89_RS09045 (1901891) 1901891..1901941 - 51 WP_001364200.1 his operon leader peptide -
QQG89_RS09050 (1902224) 1902224..1902475 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QQG89_RS09055 (1902472) 1902472..1902726 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QQG89_RS09060 (1902809) 1902809..1903633 + 825 WP_000754737.1 SDR family oxidoreductase -
QQG89_RS09065 (1903679) 1903679..1904608 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QQG89_RS09070 (1904823) 1904823..1904885 + 63 WP_010723108.1 membrane protein YoeI -
QQG89_RS09075 (1904875) 1904875..1906233 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T297114 WP_000767822.1 NZ_OX637961:1902472-1902726 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT297114 WP_001259255.1 NZ_OX637961:1902224-1902475 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References