297108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 184976..186294 Replicon chromosome
Accession NZ_OX637961
Organism Escherichia coli O25b:H4-ST131 isolate 86

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QQG89_RS00875 Protein ID WP_001262467.1
Coordinates 185287..186294 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QQG89_RS00870 Protein ID WP_001312177.1
Coordinates 184976..185287 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG89_RS00845 (180508) 180508..181527 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QQG89_RS00850 (181537) 181537..182439 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QQG89_RS00855 (182450) 182450..183433 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QQG89_RS00860 (183430) 183430..184443 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QQG89_RS00865 (184668) 184668..184991 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QQG89_RS00870 (184976) 184976..185287 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QQG89_RS00875 (185287) 185287..186294 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QQG89_RS00880 (186311) 186311..187582 - 1272 WP_001545666.1 amino acid permease -
- (187944) 187944..188009 - 66 NuclAT_27 - -
- (187944) 187944..188009 - 66 NuclAT_27 - -
- (187944) 187944..188009 - 66 NuclAT_27 - -
- (187944) 187944..188009 - 66 NuclAT_27 - -
QQG89_RS00885 (188058) 188058..188165 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (188427) 188427..188484 - 58 NuclAT_26 - -
- (188427) 188427..188484 - 58 NuclAT_26 - -
- (188427) 188427..188484 - 58 NuclAT_26 - -
- (188427) 188427..188484 - 58 NuclAT_26 - -
QQG89_RS00890 (188541) 188541..188648 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QQG89_RS00895 (189024) 189024..189131 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QQG89_RS00900 (189217) 189217..190896 - 1680 Protein_177 cellulose biosynthesis protein BcsG -
QQG89_RS00905 (190893) 190893..191084 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T297108 WP_001262467.1 NZ_OX637961:185287-186294 [Escherichia coli O25b:H4-ST131]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT297108 WP_001312177.1 NZ_OX637961:184976-185287 [Escherichia coli O25b:H4-ST131]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References