Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 602824..603623 Replicon chromosome
Accession NZ_OX637959
Organism Escherichia coli O25b:H4-ST131 isolate 32

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QQG88_RS02970 Protein ID WP_000347251.1
Coordinates 602824..603288 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QQG88_RS02975 Protein ID WP_001296435.1
Coordinates 603288..603623 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG88_RS02940 (597825) 597825..598259 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QQG88_RS02945 (598277) 598277..599155 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QQG88_RS02950 (599145) 599145..599924 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QQG88_RS02955 (599935) 599935..600408 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QQG88_RS02960 (600431) 600431..601711 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QQG88_RS02965 (601960) 601960..602769 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QQG88_RS02970 (602824) 602824..603288 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QQG88_RS02975 (603288) 603288..603623 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QQG88_RS02980 (603772) 603772..605343 - 1572 WP_001273763.1 galactarate dehydratase -
QQG88_RS02985 (605718) 605718..607052 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QQG88_RS02990 (607068) 607068..607838 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T297083 WP_000347251.1 NZ_OX637959:c603288-602824 [Escherichia coli O25b:H4-ST131]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT297083 WP_001296435.1 NZ_OX637959:c603623-603288 [Escherichia coli O25b:H4-ST131]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CJ20


Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References