Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1958077..1958590 Replicon chromosome
Accession NZ_OX461103
Organism Streptococcus agalactiae isolate MRI Z2-149

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag QOR71_RS09885 Protein ID WP_000481712.1
Coordinates 1958077..1958331 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag QOR71_RS09890 Protein ID WP_000387490.1
Coordinates 1958324..1958590 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR71_RS09865 1953848..1956349 - 2502 WP_000239404.1 ATP-binding protein -
QOR71_RS09870 1956370..1956780 - 411 WP_000390749.1 conjugal transfer protein -
QOR71_RS09875 1956784..1957050 - 267 WP_001055037.1 hypothetical protein -
QOR71_RS09880 1957071..1958024 - 954 WP_000565541.1 conjugal transfer protein -
QOR71_RS09885 1958077..1958331 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
QOR71_RS09890 1958324..1958590 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QOR71_RS09895 1958735..1959208 - 474 WP_000560386.1 hypothetical protein -
QOR71_RS09900 1959216..1959698 - 483 WP_000383283.1 antirestriction protein ArdA -
QOR71_RS09905 1959751..1960023 - 273 WP_000072643.1 hypothetical protein -
QOR71_RS09910 1960155..1960508 - 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
QOR71_RS09915 1960501..1960731 - 231 WP_001866982.1 helix-turn-helix transcriptional regulator -
QOR71_RS09920 1960718..1961095 - 378 WP_000287185.1 hypothetical protein -
QOR71_RS09925 1961111..1962343 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1942910..1982507 39597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T297052 WP_000481712.1 NZ_OX461103:c1958331-1958077 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT297052 WP_000387490.1 NZ_OX461103:c1958590-1958324 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References