Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1905374..1905887 Replicon chromosome
Accession NZ_OX460942
Organism Streptococcus agalactiae isolate MRI Z2-158

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag QOR48_RS09725 Protein ID WP_000481712.1
Coordinates 1905374..1905628 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag QOR48_RS09730 Protein ID WP_000387490.1
Coordinates 1905621..1905887 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QOR48_RS09705 1901145..1903646 - 2502 WP_000239404.1 ATP-binding protein -
QOR48_RS09710 1903667..1904077 - 411 WP_000390749.1 conjugal transfer protein -
QOR48_RS09715 1904081..1904347 - 267 WP_001055037.1 hypothetical protein -
QOR48_RS09720 1904368..1905321 - 954 WP_000565541.1 conjugal transfer protein -
QOR48_RS09725 1905374..1905628 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
QOR48_RS09730 1905621..1905887 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QOR48_RS09735 1906032..1906505 - 474 WP_000560386.1 hypothetical protein -
QOR48_RS09740 1906513..1906995 - 483 WP_000383283.1 antirestriction protein ArdA -
QOR48_RS09745 1907048..1907320 - 273 WP_000072643.1 hypothetical protein -
QOR48_RS09750 1907452..1907805 - 354 WP_000571928.1 helix-turn-helix transcriptional regulator -
QOR48_RS09755 1907798..1908028 - 231 WP_001866982.1 helix-turn-helix transcriptional regulator -
QOR48_RS09760 1908015..1908392 - 378 WP_000287185.1 hypothetical protein -
QOR48_RS09765 1908408..1909640 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1890207..1929809 39602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T297016 WP_000481712.1 NZ_OX460942:c1905628-1905374 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT297016 WP_000387490.1 NZ_OX460942:c1905887-1905621 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References