Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2983810..2984412 Replicon chromosome
Accession NZ_OX442412
Organism Salmonella enterica subsp. enterica serovar Rissen isolate pure strain

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag QM550_RS14820 Protein ID WP_023138876.1
Coordinates 2983810..2984121 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QM550_RS14825 Protein ID WP_000362050.1
Coordinates 2984122..2984412 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM550_RS14795 (2979767) 2979767..2980366 + 600 WP_000965695.1 glucose-1-phosphatase -
QM550_RS14800 (2980360) 2980360..2981232 + 873 WP_000921423.1 virulence factor BrkB family protein -
QM550_RS14805 (2981229) 2981229..2981666 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
QM550_RS14810 (2981711) 2981711..2982652 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QM550_RS14815 (2982678) 2982678..2983592 - 915 WP_023138875.1 alpha/beta hydrolase -
QM550_RS14820 (2983810) 2983810..2984121 + 312 WP_023138876.1 hypothetical protein Toxin
QM550_RS14825 (2984122) 2984122..2984412 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QM550_RS14830 (2984459) 2984459..2985388 - 930 WP_023138877.1 formate dehydrogenase accessory protein FdhE -
QM550_RS14835 (2985385) 2985385..2986020 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QM550_RS14840 (2986017) 2986017..2986919 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T296966 WP_023138876.1 NZ_OX442412:2983810-2984121 [Salmonella enterica subsp. enterica serovar Rissen]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT296966 WP_000362050.1 NZ_OX442412:2984122-2984412 [Salmonella enterica subsp. enterica serovar Rissen]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References