Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) bsrG-SR6/-
Location 2262271..2262560 Replicon chromosome
Accession NZ_OX419557
Organism Bacillus subtilis isolate NRS6186

Toxin (Protein)


Gene name bsrG Uniprot ID L8EAY0
Locus tag KJP72_RS11735 Protein ID WP_009967548.1
Coordinates 2262271..2262387 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name SR6
Locus tag -
Coordinates 2262382..2262560 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJP72_RS11705 (2257732) 2257732..2258970 - 1239 WP_142743355.1 MFS transporter -
KJP72_RS11710 (2259083) 2259083..2260333 - 1251 WP_114168635.1 UV damage repair protein UvrX -
KJP72_RS11715 (2260326) 2260326..2260658 - 333 WP_119996914.1 YolD-like family protein -
KJP72_RS11720 (2260832) 2260832..2261167 + 336 WP_213386198.1 hypothetical protein -
KJP72_RS11725 (2261210) 2261210..2261566 - 357 WP_213386197.1 hypothetical protein -
KJP72_RS11730 (2261572) 2261572..2262039 - 468 WP_213386196.1 DUF4879 domain-containing protein -
KJP72_RS11735 (2262271) 2262271..2262387 + 117 WP_009967548.1 type I toxin-antitoxin system toxin BsrG Toxin
- (2262382) 2262382..2262560 - 179 NuclAT_1 - Antitoxin
- (2262382) 2262382..2262560 - 179 NuclAT_1 - Antitoxin
- (2262382) 2262382..2262560 - 179 NuclAT_1 - Antitoxin
- (2262382) 2262382..2262560 - 179 NuclAT_1 - Antitoxin
KJP72_RS11740 (2262665) 2262665..2263198 - 534 WP_163260209.1 GNAT family protein -
KJP72_RS11745 (2263234) 2263234..2263812 - 579 WP_069322724.1 SMI1/KNR4 family protein -
KJP72_RS11750 (2263868) 2263868..2264329 - 462 WP_042976288.1 SMI1/KNR4 family protein -
KJP72_RS11755 (2264345) 2264345..2266110 - 1766 Protein_2264 T7SS effector LXG polymorphic toxin -
KJP72_RS11760 (2266362) 2266362..2267363 + 1002 WP_250628844.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2138968..2272031 133063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-38)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4336.39 Da        Isoelectric Point: 10.1022

>T296801 WP_009967548.1 NZ_OX419557:2262271-2262387 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Download         Length: 117 bp

Antitoxin


Download         Length: 179 bp

>AT296801 NZ_OX419557:c2262560-2262382 [Bacillus subtilis]
AATGATACAAATAATTATTTTTTGCATTTTGATTTGTAGAAATGCATAAAATAAAAAGACCAGGGTGCTACCAACACCCC
AGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCAGATGTATGTGACATAGTAGACCAACCCTTTAGGGTCGCAAT
CTCAAGGGGAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7EVU9

Antitoxin

Download structure file

References