Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3986059..3986735 Replicon chromosome
Accession NZ_OX371412
Organism Streptomyces albidoflavus strain CCOS 2040 isolate Stup19_F108

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag OZE77_RS17560 Protein ID WP_018471256.1
Coordinates 3986059..3986421 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OZE77_RS17565 Protein ID WP_018471255.1
Coordinates 3986418..3986735 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE77_RS17535 (CCOS2040_17650) 3982080..3982496 - 417 WP_003949884.1 ATP-binding protein -
OZE77_RS17540 (CCOS2040_17655) 3982496..3982876 - 381 WP_003949885.1 STAS domain-containing protein -
OZE77_RS17545 (CCOS2040_17660) 3982873..3983727 - 855 WP_030308234.1 STAS domain-containing protein -
OZE77_RS17550 (CCOS2040_17665) 3984031..3984273 + 243 WP_030308232.1 hypothetical protein -
OZE77_RS17555 (CCOS2040_17670) 3984363..3986060 - 1698 WP_031177816.1 hypothetical protein -
OZE77_RS17560 3986059..3986421 + 363 WP_018471256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OZE77_RS17565 (CCOS2040_17675) 3986418..3986735 + 318 WP_018471255.1 helix-turn-helix transcriptional regulator Antitoxin
OZE77_RS17570 (CCOS2040_17680) 3986814..3987596 - 783 WP_003949890.1 ABC transporter permease -
OZE77_RS17575 (CCOS2040_17685) 3987593..3988567 - 975 WP_003949891.1 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein -
OZE77_RS17580 (CCOS2040_17690) 3988671..3989540 - 870 WP_267766697.1 DUF4097 family beta strand repeat-containing protein -
OZE77_RS17585 (CCOS2040_17695) 3989642..3990172 - 531 WP_003949893.1 toxin-antitoxin system HicB family antitoxin -
OZE77_RS17590 (CCOS2040_17700) 3990368..3991429 - 1062 WP_031177814.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.36 Da        Isoelectric Point: 4.6168

>T296743 WP_018471256.1 NZ_OX371412:3986059-3986421 [Streptomyces albidoflavus]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQWTEWYQEAIPLAEQRYALYLKEREREEGGRP

Download         Length: 363 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11558.05 Da        Isoelectric Point: 9.8236

>AT296743 WP_018471255.1 NZ_OX371412:3986418-3986735 [Streptomyces albidoflavus]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References