Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 474578..475121 Replicon chromosome
Accession NC_021723
Organism Lactobacillus rhamnosus LOCK900

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag LOCK900_RS13565 Protein ID WP_005709630.1
Coordinates 474578..474865 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag LOCK900_RS02250 Protein ID WP_005714439.1
Coordinates 474849..475121 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOCK900_RS02215 469826..470194 - 369 WP_005686376.1 PTS-dependent dihydroxyacetone kinase phosphotransferase subunit DhaM -
LOCK900_RS02220 470228..470809 - 582 WP_005709619.1 dihydroxyacetone kinase subunit L -
LOCK900_RS02225 470796..471815 - 1020 WP_005709622.1 dihydroxyacetone kinase subunit DhaK -
LOCK900_RS02230 472009..472437 - 429 WP_005714437.1 OsmC family protein -
LOCK900_RS02235 472548..472727 - 180 WP_005709626.1 hypothetical protein -
LOCK900_RS02240 472945..474354 - 1410 WP_005714438.1 3'-5' exonuclease -
LOCK900_RS13565 474578..474865 - 288 WP_005709630.1 type II toxin-antitoxin system YafQ family toxin Toxin
LOCK900_RS02250 474849..475121 - 273 WP_005714439.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOCK900_RS02255 475235..475528 + 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
LOCK900_RS02260 475610..476773 + 1164 WP_005709634.1 MFS transporter -
LOCK900_RS02265 476936..478309 - 1374 WP_005714442.1 MFS transporter -
LOCK900_RS02270 478422..479522 + 1101 WP_005709638.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-67)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10888.77 Da        Isoelectric Point: 10.9032

>T29674 WP_005709630.1 NC_021723:c474865-474578 [Lactobacillus rhamnosus LOCK900]
MMLTINRTRTFKRQFKHLLRQGKDMTKLATAIDTLQRQDRVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALIL
MLLATGTHRDTLNIE

Download         Length: 288 bp

>T29674 NC_021723:c474865-474578 [Lactobacillus rhamnosus LOCK900]
ATGATGTTGACGATTAATCGCACGCGCACTTTCAAACGACAATTTAAACATCTTCTTAGGCAAGGTAAAGATATGACGAA
ACTTGCAACTGCAATTGATACTTTGCAGCGTCAAGATCGTGTAAAATTAGCTTCTTTACACGACCATGCTTTAAAGGGTG
CTCACAGCGGCGAACGAGCATTGCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTA
ATGCTTCTTGCAACAGGCACACACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10073.49 Da        Isoelectric Point: 5.1154

>AT29674 WP_005714439.1 NC_021723:c475121-474849 [Lactobacillus rhamnosus LOCK900]
METKSRISVRIDTKTKERALHVLNSMGLDMSSAINMYLKRIGDTGELPFTPEMSFADQLQAAEADVKAGRTKSFKTVDAL
MKDLYNDVDD

Download         Length: 273 bp

>AT29674 NC_021723:c475121-474849 [Lactobacillus rhamnosus LOCK900]
ATGGAAACAAAATCCCGTATCAGCGTGCGAATTGATACCAAAACCAAAGAACGGGCTCTCCATGTCCTCAATAGCATGGG
ACTAGATATGTCCTCAGCTATTAACATGTATTTGAAACGCATTGGTGACACTGGTGAGTTGCCATTTACACCTGAAATGT
CGTTCGCCGATCAGCTTCAAGCTGCAGAAGCTGATGTTAAAGCGGGACGAACTAAGAGCTTCAAGACCGTTGATGCCCTG
ATGAAGGATTTATACAATGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References