Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2004389..2005035 Replicon chromosome
Accession NZ_OX359182
Organism Klebsiella pneumoniae strain KP34 isolate 2018-347802-001-01

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag OM989_RS09820 Protein ID WP_016529833.1
Coordinates 2004688..2005035 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag OM989_RS09815 Protein ID WP_002920557.1
Coordinates 2004389..2004688 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM989_RS09795 (2000595) 2000595..2001353 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
OM989_RS09800 (2001403) 2001403..2002233 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
OM989_RS09805 (2002284) 2002284..2002613 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
OM989_RS09810 (2002818) 2002818..2004326 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
OM989_RS09815 (2004389) 2004389..2004688 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
OM989_RS09820 (2004688) 2004688..2005035 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM989_RS09825 (2005201) 2005201..2007648 - 2448 WP_002920561.1 glycogen phosphorylase -
OM989_RS09830 (2007666) 2007666..2009099 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T296717 WP_016529833.1 NZ_OX359182:c2005035-2004688 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT296717 WP_002920557.1 NZ_OX359182:c2004688-2004389 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References