Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1866939..1867458 Replicon chromosome
Accession NZ_OX352944
Organism Streptococcus suis isolate 861160_LM_H

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag QNH68_RS08965 Protein ID WP_012775363.1
Coordinates 1866939..1867196 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag QNH68_RS08970 Protein ID WP_002939010.1
Coordinates 1867198..1867458 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH68_RS08945 1862660..1864390 - 1731 WP_024387386.1 membrane protein -
QNH68_RS08950 1864851..1865324 - 474 WP_024378560.1 IS200/IS605 family transposase -
QNH68_RS08955 1865504..1866376 - 873 WP_024387385.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
QNH68_RS08960 1866395..1866925 - 531 WP_074390182.1 DUF1697 domain-containing protein -
QNH68_RS08965 1866939..1867196 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
QNH68_RS08970 1867198..1867458 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QNH68_RS08975 1867534..1867989 - 456 WP_074390181.1 8-oxo-dGTP diphosphatase -
QNH68_RS08980 1867996..1868325 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
QNH68_RS08985 1868315..1868602 - 288 WP_012028535.1 hypothetical protein -
QNH68_RS08990 1868700..1869068 - 369 WP_012775453.1 hypothetical protein -
QNH68_RS08995 1869061..1869630 - 570 WP_012775700.1 ribonuclease M5 -
QNH68_RS09000 1869614..1870396 - 783 WP_012028536.1 TatD family hydrolase -
QNH68_RS09005 1870503..1870640 - 138 WP_002939016.1 50S ribosomal protein L34 -
QNH68_RS09010 1870808..1871803 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1843516..1870396 26880
- flank IS/Tn - - 1864851..1865324 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T296681 WP_012775363.1 NZ_OX352944:c1867196-1866939 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT296681 WP_002939010.1 NZ_OX352944:c1867458-1867198 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References