29667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2258686..2260009 Replicon chromosome
Accession NC_021717
Organism Alteromonas macleodii str. Ionian Sea U7

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag I876_RS09805 Protein ID WP_020743583.1
Coordinates 2258686..2259696 (-) Length 337 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag I876_RS09810 Protein ID WP_020743584.1
Coordinates 2259689..2260009 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I876_RS09775 2253822..2254253 - 432 Protein_1918 IS5/IS1182 family transposase -
I876_RS09780 2254428..2255435 - 1008 WP_020745894.1 zinc-dependent alcohol dehydrogenase family protein -
I876_RS09785 2255458..2256465 - 1008 WP_020745896.1 zinc-dependent alcohol dehydrogenase family protein -
I876_RS09790 2256540..2257298 - 759 WP_012518416.1 SDR family oxidoreductase -
I876_RS09795 2257454..2258347 + 894 WP_041912891.1 LysR family transcriptional regulator -
I876_RS09805 2258686..2259696 - 1011 WP_020743583.1 HipA domain-containing protein Toxin
I876_RS09810 2259689..2260009 - 321 WP_020743584.1 HipA N-terminal domain-containing protein Antitoxin
I876_RS09815 2259997..2260302 - 306 WP_020743585.1 hypothetical protein -
I876_RS09820 2260782..2261297 - 516 WP_148290597.1 hypothetical protein -
I876_RS09825 2261452..2262372 + 921 WP_020745900.1 hypothetical protein -
I876_RS09830 2262553..2262912 + 360 WP_020745901.1 hypothetical protein -
I876_RS09835 2263018..2263998 - 981 WP_020745903.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2253822..2254289 467
- flank IS/Tn - - 2263018..2263998 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-301)

Antitoxin

HipA, N-terminal subdomain 1

(6-99)


Sequences

Toxin        


Download         Length: 337 a.a.        Molecular weight: 37868.21 Da        Isoelectric Point: 5.8831

>T29667 WP_020743583.1 NC_021717:c2259696-2258686 [Alteromonas mediterranea U7]
MNNCKITLKKLAKSSKYDGFSDAGVRHLFGTLKVSPIVDFDRQDLESYPTSHNGKMSISGFQPKMSATVIDDKLVLVKEN
GTFIIKPSPAQFPNLAENEHAIMTLASICKFPVPPFGLIQLNNGELAFIIKRYDRENGIKLHQEQLDSAMGVDDKFGNIS
GSQAVSYSKAGAFITKNLKALQEYAEFYRRVIFSYVVGNNDHHLRNFSLLYTSNGALPTLSPVYDVVSVEPYGEYFLSSY
MALPLLTSQESDNDEDIDTGFDRKYGQYDRQDFIRLGEEIGLKMQVAVKLLDDLLKGIEKAIPIVSVSFMDAEHKQSIER
LIRHRIMILRDEDTEL

Download         Length: 1011 bp

>T29667 NC_021717:c2259696-2258686 [Alteromonas mediterranea U7]
ATGAATAACTGTAAGATAACACTTAAAAAGCTAGCCAAGAGCTCGAAATATGATGGGTTTTCTGATGCCGGTGTACGTCA
CCTTTTTGGGACGTTAAAGGTATCGCCAATTGTAGATTTTGATAGGCAGGATTTAGAATCCTATCCGACGTCACATAACG
GTAAGATGAGCATCTCTGGGTTTCAGCCTAAAATGTCAGCGACGGTCATTGACGACAAGCTTGTACTGGTAAAAGAGAAC
GGGACGTTCATTATTAAGCCATCACCCGCTCAATTTCCAAATCTGGCAGAAAATGAGCACGCTATTATGACACTGGCGAG
CATCTGTAAATTTCCGGTTCCTCCCTTCGGCCTTATCCAACTTAATAACGGTGAGTTAGCATTCATCATAAAGCGCTATG
ATCGTGAAAATGGTATTAAACTTCACCAAGAGCAACTGGATAGCGCAATGGGCGTTGATGACAAGTTCGGCAATATTAGT
GGTTCACAAGCCGTAAGTTATTCCAAAGCTGGCGCTTTTATCACGAAAAACCTAAAAGCGTTACAAGAATATGCTGAATT
TTATCGTCGTGTTATCTTCAGCTACGTCGTTGGAAACAATGATCACCATTTAAGAAATTTCTCTCTCTTGTATACAAGTA
ATGGTGCACTTCCGACGTTATCACCCGTTTATGACGTTGTATCAGTCGAGCCTTATGGTGAATACTTTCTCAGTTCCTAT
ATGGCCCTTCCACTCTTGACGTCACAAGAAAGCGATAATGATGAAGATATTGATACTGGCTTTGATCGAAAATATGGGCA
GTATGATAGGCAAGACTTCATTAGATTAGGTGAAGAGATTGGTTTGAAAATGCAGGTGGCTGTGAAACTACTTGATGACT
TATTAAAGGGAATCGAGAAAGCGATACCAATCGTGTCTGTATCGTTTATGGATGCTGAGCACAAACAAAGTATAGAACGC
TTAATAAGGCATCGCATTATGATCCTGAGAGATGAAGATACAGAATTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12111.87 Da        Isoelectric Point: 4.8782

>AT29667 WP_020743584.1 NC_021717:c2260009-2259689 [Alteromonas mediterranea U7]
MGELSAEVFLYDVHVGILKKHPKGYSFKYKSDYFGPPLSLSLPLRASLYESDTLFPFFKSLLPEGWLLKQYARAQRIDER
DEFSLLVNNGEDLLGAVAIKPIEENE

Download         Length: 321 bp

>AT29667 NC_021717:c2260009-2259689 [Alteromonas mediterranea U7]
ATGGGCGAGCTAAGCGCTGAAGTCTTCTTATATGATGTGCACGTCGGTATTTTAAAGAAGCATCCAAAGGGTTACTCGTT
TAAATATAAAAGCGATTACTTTGGTCCTCCACTGTCGTTGTCTTTACCTTTACGTGCATCGCTTTATGAATCTGACACGC
TTTTCCCTTTTTTTAAGTCTCTACTACCTGAAGGTTGGCTTTTAAAGCAGTATGCTCGTGCACAAAGAATCGATGAGCGT
GATGAATTTTCGCTTCTTGTAAATAACGGTGAAGACTTGCTCGGAGCTGTAGCTATAAAGCCTATTGAAGAAAATGAATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References