Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1466271..1466857 Replicon chromosome
Accession NZ_OX352324
Organism Pseudomonas sp. MM221

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag OM991_RS06810 Protein ID WP_264362023.1
Coordinates 1466579..1466857 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag OM991_RS06805 Protein ID WP_264362022.1
Coordinates 1466271..1466570 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM991_RS06780 (GLGCALEP_01416) 1462198..1463007 + 810 WP_264362018.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
OM991_RS06785 (GLGCALEP_01417) 1463040..1463450 - 411 WP_264362019.1 SufE family protein -
OM991_RS06790 (GLGCALEP_01418) 1463447..1464652 - 1206 WP_264362020.1 cysteine desulfurase -
OM991_RS06795 (GLGCALEP_01419) 1464734..1465768 - 1035 WP_264362021.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
OM991_RS06800 (GLGCALEP_01421) 1465800..1466146 - 347 Protein_1324 ArsC family reductase -
OM991_RS06805 (GLGCALEP_01422) 1466271..1466570 - 300 WP_264362022.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
OM991_RS06810 1466579..1466857 - 279 WP_264362023.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM991_RS06815 (GLGCALEP_01423) 1467110..1468756 + 1647 WP_264362024.1 Na+/H+ antiporter -
OM991_RS06820 (GLGCALEP_01424) 1468862..1470058 - 1197 WP_264362025.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10460.90 Da        Isoelectric Point: 9.4173

>T296636 WP_264362023.1 NZ_OX352324:c1466857-1466579 [Pseudomonas sp. MM221]
MIRSFSCAETEALFCTGKTRRWSDIKSVAERKLAMLDAATALRDLRSPPGNRLESLSGNRAGQHSIRVNDQWRVCFTWTE
HGPVNVKIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 5.0892

>AT296636 WP_264362022.1 NZ_OX352324:c1466570-1466271 [Pseudomonas sp. MM221]
MLKNGMRPIHPGEILREDFQKEMGFSAAALARALGVATPTVNNILRERGGISADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQQHGDEIIESVQRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References