Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1466627..1467213 Replicon chromosome
Accession NZ_OX352322
Organism Pseudomonas sp. MM223

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ONI07_RS06765 Protein ID WP_264362023.1
Coordinates 1466935..1467213 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ONI07_RS06760 Protein ID WP_264362022.1
Coordinates 1466627..1466926 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONI07_RS06735 (DBADOPDK_01382) 1462553..1463362 + 810 WP_264362018.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
ONI07_RS06740 (DBADOPDK_01383) 1463395..1463805 - 411 WP_264362019.1 SufE family protein -
ONI07_RS06745 (DBADOPDK_01384) 1463802..1465007 - 1206 WP_264362020.1 cysteine desulfurase -
ONI07_RS06750 (DBADOPDK_01385) 1465089..1466123 - 1035 WP_264362021.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
ONI07_RS06755 (DBADOPDK_01386) 1466155..1466502 - 348 WP_003252272.1 ArsC family reductase -
ONI07_RS06760 (DBADOPDK_01387) 1466627..1466926 - 300 WP_264362022.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
ONI07_RS06765 1466935..1467213 - 279 WP_264362023.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONI07_RS06770 (DBADOPDK_01388) 1467466..1469113 + 1648 Protein_1318 Na+/H+ antiporter -
ONI07_RS06775 (DBADOPDK_01389) 1469219..1470415 - 1197 WP_264362025.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10460.90 Da        Isoelectric Point: 9.4173

>T296626 WP_264362023.1 NZ_OX352322:c1467213-1466935 [Pseudomonas sp. MM223]
MIRSFSCAETEALFCTGKTRRWSDIKSVAERKLAMLDAATALRDLRSPPGNRLESLSGNRAGQHSIRVNDQWRVCFTWTE
HGPVNVKIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 5.0892

>AT296626 WP_264362022.1 NZ_OX352322:c1466926-1466627 [Pseudomonas sp. MM223]
MLKNGMRPIHPGEILREDFQKEMGFSAAALARALGVATPTVNNILRERGGISADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQQHGDEIIESVQRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References