Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4503285..4503859 Replicon chromosome
Accession NZ_OX352320
Organism Rheinheimera sp. MM224

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OM978_RS20860 Protein ID WP_264346981.1
Coordinates 4503581..4503859 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OM978_RS20855 Protein ID WP_264344344.1
Coordinates 4503285..4503581 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM978_RS20840 (JAMGFMIE_04190) 4500011..4500631 + 621 WP_264344341.1 LysE family translocator -
OM978_RS20845 (JAMGFMIE_04191) 4500897..4502438 + 1542 WP_264344342.1 alpha-L-arabinofuranosidase C-terminal domain-containing protein -
OM978_RS20850 (JAMGFMIE_04192) 4502502..4502999 - 498 WP_264344343.1 DUF1993 domain-containing protein -
OM978_RS20855 (JAMGFMIE_04193) 4503285..4503581 - 297 WP_264344344.1 HigA family addiction module antitoxin Antitoxin
OM978_RS20860 (JAMGFMIE_04194) 4503581..4503859 - 279 WP_264346981.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OM978_RS20865 (JAMGFMIE_04195) 4504015..4504413 + 399 WP_233010886.1 BlaI/MecI/CopY family transcriptional regulator -
OM978_RS20870 (JAMGFMIE_04196) 4504415..4505797 + 1383 WP_264344345.1 M23/M56 family metallopeptidase -
OM978_RS20875 (JAMGFMIE_04197) 4505814..4506941 + 1128 WP_264344346.1 serine hydrolase domain-containing protein -
OM978_RS20880 (JAMGFMIE_04198) 4506958..4507857 + 900 WP_264344347.1 alpha/beta hydrolase-fold protein -
OM978_RS20885 (JAMGFMIE_04199) 4507919..4508347 + 429 WP_264344348.1 nucleotidyltransferase substrate binding protein -
OM978_RS20890 (JAMGFMIE_04200) 4508340..4508642 + 303 WP_264344349.1 nucleotidyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.14 Da        Isoelectric Point: 9.9127

>T296624 WP_264346981.1 NZ_OX352320:c4503859-4503581 [Rheinheimera sp. MM224]
MIKNFKHKGLERFYKTGSTAGIKAKHQNRLRLILSNLDQAEAIDDMDLPGLRLHELSGDRKGIWSVTVNGNWRVTFRFVG
RDAEIVNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 6.8789

>AT296624 WP_264344344.1 NZ_OX352320:c4503581-4503285 [Rheinheimera sp. MM224]
MSMHNPAHPGEILKELIIEPLALTVTDVSAHLNISRKTLSKVLNARGAITPEMALRLELAFSKPSAEHWLRLQNAYDLWL
VREQQAQLQVLPYQLEFA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References