Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1786968..1787539 Replicon chromosome
Accession NZ_OX352319
Organism Pseudomonas sp. MM227

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ONG87_RS08195 Protein ID WP_264382605.1
Coordinates 1787273..1787539 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ONG87_RS08190 Protein ID WP_122478697.1
Coordinates 1786968..1787264 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONG87_RS08165 (AHFPHNDE_01633) 1782446..1783330 - 885 WP_240998817.1 AraC family transcriptional regulator -
ONG87_RS08170 (AHFPHNDE_01634) 1783926..1784885 - 960 WP_264382603.1 transcriptional regulator FtrA -
ONG87_RS08175 (AHFPHNDE_01635) 1784981..1785418 + 438 WP_264382604.1 rhodanese-like domain-containing protein -
ONG87_RS08180 1785406..1785621 + 216 WP_192054211.1 hypothetical protein -
ONG87_RS08185 (AHFPHNDE_01636) 1785837..1786805 + 969 WP_122478698.1 XdhC family protein -
ONG87_RS08190 (AHFPHNDE_01637) 1786968..1787264 - 297 WP_122478697.1 HigA family addiction module antitoxin Antitoxin
ONG87_RS08195 1787273..1787539 - 267 WP_264382605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ONG87_RS08200 (AHFPHNDE_01638) 1787740..1788603 - 864 WP_122478693.1 MBL fold metallo-hydrolase -
ONG87_RS08205 (AHFPHNDE_01639) 1788696..1789025 + 330 WP_122478691.1 metalloregulator ArsR/SmtB family transcription factor -
ONG87_RS08210 (AHFPHNDE_01640) 1789131..1790696 + 1566 WP_264382606.1 bifunctional protein tyrosine phosphatase family protein/NAD(P)/FAD-dependent oxidoreductase -
ONG87_RS08215 (AHFPHNDE_01641) 1790701..1791498 + 798 WP_264382841.1 sulfite exporter TauE/SafE family protein -
ONG87_RS08220 (AHFPHNDE_01642) 1791603..1792490 - 888 WP_264382607.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-88)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10155.51 Da        Isoelectric Point: 8.5654

>T296618 WP_264382605.1 NZ_OX352319:c1787539-1787273 [Pseudomonas sp. MM227]
MIRSFACADTEALFTTGRTRRWADIKSVAERKLAALHAAKELRDLRSPPGNRLHTLEGDRAGQHNMQWRVCFIWTQNGPE
HVEIVDYH

Download         Length: 267 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10721.35 Da        Isoelectric Point: 5.5892

>AT296618 WP_122478697.1 NZ_OX352319:c1787264-1786968 [Pseudomonas sp. MM227]
MFKNGMRPIHPGEILREDFQHEMGFSAAALARALGVSTPTVNNILLERGGVSADMALRLAVCLDTTAEFWLNLQTAYELR
KAELEHGDAIAAVQRLVA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References