Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2498216..2498733 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OOL12_RS12525 Protein ID WP_000113262.1
Coordinates 2498467..2498733 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OOL12_RS12520 Protein ID WP_000584499.1
Coordinates 2498216..2498467 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS12490 (2493914) 2493914..2494633 + 720 WP_000479576.1 amino acid ABC transporter permease -
OOL12_RS12495 (2494630) 2494630..2495361 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OOL12_RS12500 (2495458) 2495458..2496708 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OOL12_RS12505 (2496963) 2496963..2497325 + 363 WP_000819843.1 DUF4467 domain-containing protein -
OOL12_RS12510 (2497344) 2497344..2497943 + 600 WP_000162813.1 DsbA family protein -
OOL12_RS12515 (2497950) 2497950..2498051 + 102 WP_001791744.1 hypothetical protein -
OOL12_RS12520 (2498216) 2498216..2498467 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOL12_RS12525 (2498467) 2498467..2498733 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OOL12_RS12530 (2498768) 2498768..2498839 + 72 Protein_2437 hypothetical protein -
OOL12_RS12535 (2499028) 2499028..2500578 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OOL12_RS12540 (2500764) 2500764..2501231 + 468 WP_264717274.1 SRPBCC domain-containing protein -
OOL12_RS12545 (2501315) 2501315..2501497 + 183 WP_000230294.1 hypothetical protein -
OOL12_RS12550 (2501714) 2501714..2502538 + 825 WP_061732679.1 formate/nitrite transporter family protein -
OOL12_RS12555 (2502771) 2502771..2503307 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T296607 WP_000113262.1 NZ_OX344719:2498467-2498733 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT296607 WP_000584499.1 NZ_OX344719:2498216-2498467 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References