Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2441367..2441890 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OOL12_RS12250 Protein ID WP_000074048.1
Coordinates 2441624..2441890 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OOL12_RS12245 Protein ID WP_000587616.1
Coordinates 2441367..2441624 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS12225 (2436447) 2436447..2437640 + 1194 WP_000675401.1 MFS transporter -
OOL12_RS12230 (2437864) 2437864..2438613 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
OOL12_RS12235 (2438808) 2438808..2440385 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OOL12_RS12240 (2440553) 2440553..2441008 - 456 WP_000732082.1 DUF1307 domain-containing protein -
OOL12_RS12245 (2441367) 2441367..2441624 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOL12_RS12250 (2441624) 2441624..2441890 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OOL12_RS12255 (2442245) 2442245..2443312 + 1068 WP_001076684.1 M42 family metallopeptidase -
OOL12_RS12260 (2443560) 2443560..2444222 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OOL12_RS12265 (2444215) 2444215..2444991 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OOL12_RS12270 (2445387) 2445387..2446574 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T296605 WP_000074048.1 NZ_OX344719:2441624-2441890 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT296605 WP_000587616.1 NZ_OX344719:2441367-2441624 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References