Detailed information of TA system TA296602

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1120379..1120958
• Replicon: chromosome
• Accession: NZ_OX344719
• Organism: Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OOL12_RS05720
• Protein ID: WP_001025401.1
• Coordinates: 1120713..1120958 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1120379..1120744 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OOL12_RS05680 (1117120)	1117120..1117677	-	558	WP_000645048.1	DUF2815 family protein	-
OOL12_RS05685 (1117703)	1117703..1118869	-	1167	WP_000762548.1	DUF2800 domain-containing protein	-
OOL12_RS05690 (1118866)	1118866..1119228	-	363	WP_000985976.1	hypothetical protein	-
OOL12_RS05695 (1119243)	1119243..1119566	-	324	WP_000174994.1	hypothetical protein	-
OOL12_RS05700 (1119645)	1119645..1119806	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
OOL12_RS05705 (1119819)	1119819..1120082	-	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
OOL12_RS05710 (1120109)	1120109..1120324	-	216	WP_001097552.1	hypothetical protein	-
OOL12_RS05715 (1120379)	1120379..1120744	+	366	WP_001128433.1	hypothetical protein	Antitoxin
OOL12_RS05720 (1120713)	1120713..1120958	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OOL12_RS05725 (1121008)	1121008..1121226	-	219	WP_001001383.1	hypothetical protein	-
OOL12_RS05730 (1121242)	1121242..1122018	-	777	WP_001148559.1	phage antirepressor	-
OOL12_RS05735 (1122044)	1122044..1122271	-	228	WP_001030311.1	hypothetical protein	-
OOL12_RS05740 (1122443)	1122443..1123057	+	615	WP_000801423.1	XRE family transcriptional regulator	-
OOL12_RS05745 (1123073)	1123073..1123993	+	921	WP_000348133.1	exonuclease domain-containing protein	-
OOL12_RS05750 (1124089)	1124089..1124271	+	183	WP_000705240.1	hypothetical protein	-
OOL12_RS05755 (1124417)	1124417..1124767	-	351	WP_223223779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ebp / gnd	1044707..1156682	111975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T296602 WP_001025401.1 NZ_OX344719:c1120958-1120713 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT296602 NZ_OX344719:1120379-1120744 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin