Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 20011..20349 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OOL12_RS00110 Protein ID WP_011447039.1
Coordinates 20011..20187 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 20175..20349 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS00090 17841..17993 + 153 WP_001000058.1 hypothetical protein -
OOL12_RS00095 18039..18326 + 288 WP_001262621.1 hypothetical protein -
OOL12_RS00100 18382..18756 + 375 WP_000340977.1 hypothetical protein -
OOL12_RS00105 19129..19902 + 774 WP_000750412.1 staphylococcal enterotoxin type A -
OOL12_RS00110 20011..20187 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 20175..20349 - 175 - - Antitoxin
OOL12_RS00120 20399..20653 + 255 WP_000611508.1 phage holin -
OOL12_RS00125 20665..21420 + 756 WP_000861038.1 CHAP domain-containing protein -
OOL12_RS00130 21611..22102 + 492 WP_000920038.1 staphylokinase -
OOL12_RS00135 22753..23088 + 336 Protein_26 SH3 domain-containing protein -
OOL12_RS00140 23599..23949 + 351 WP_000702263.1 complement inhibitor SCIN-A -
OOL12_RS00145 24002..24262 - 261 WP_001791826.1 hypothetical protein -
OOL12_RS00150 24573..24752 - 180 WP_000669791.1 hypothetical protein -
OOL12_RS00155 25124..25321 - 198 WP_000239610.1 phospholipase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sea / sak / scn 1..23949 23948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T296597 WP_011447039.1 NZ_OX344719:20011-20187 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT296597 NZ_OX344719:c20349-20175 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References