Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 710930..711507 Replicon chromosome
Accession NZ_OX336137
Organism Nitrospina watsonii strain 347 isolate Nitrospina watsonii

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QML71_RS03185 Protein ID WP_282010455.1
Coordinates 710930..711214 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QML71_RS03190 Protein ID WP_282010456.1
Coordinates 711214..711507 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QML71_RS03160 (NSPWAT_0654) 707235..707708 - 474 WP_282010450.1 hypothetical protein -
QML71_RS03165 (NSPWAT_0655) 708466..709122 + 657 WP_282010451.1 AAA family ATPase -
QML71_RS03170 (NSPWAT_0656) 709131..709427 + 297 WP_282010452.1 hypothetical protein -
QML71_RS03175 (NSPWAT_0657) 709867..710436 + 570 WP_282010453.1 hypothetical protein -
QML71_RS03180 (NSPWAT_0658) 710610..710837 + 228 WP_282010454.1 hypothetical protein -
QML71_RS03185 (NSPWAT_0659) 710930..711214 + 285 WP_282010455.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QML71_RS03190 (NSPWAT_0660) 711214..711507 + 294 WP_282010456.1 HigA family addiction module antitoxin Antitoxin
QML71_RS03195 (NSPWAT_0661) 711542..711796 + 255 WP_282010457.1 HigA family addiction module antitoxin -
QML71_RS03200 (NSPWAT_0662) 711816..714581 + 2766 WP_282010458.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
QML71_RS03205 (NSPWAT_0663) 714578..716047 + 1470 WP_282010459.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-88)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10904.59 Da        Isoelectric Point: 10.3389

>T296581 WP_282010455.1 NZ_OX336137:710930-711214 [Nitrospina watsonii]
MKIKKVRHRGLKRFIEKNDPSGLPSAKVEKVRDIITALVVAESPNDLPVFPGWRLHRLKGDRKGQWSISVTGNWRITFVL
EDDTIQELNLEDYH

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11124.98 Da        Isoelectric Point: 9.9205

>AT296581 WP_282010456.1 NZ_OX336137:711214-711507 [Nitrospina watsonii]
MKNIGMIPSHPGEFVRRQVLEPLELSISHAAEILDIRRATLSDLVNGKTSLTPEMAFRLEKAFDVKMDFLLRMQALYDTA
RMRQSGKNIDVVRFHPN

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References