Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4257885..4258143 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LQ200_RS20500 Protein ID WP_000809168.1
Coordinates 4257885..4258037 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4258086..4258143 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS20480 4253127..4253840 - 714 WP_001102367.1 acidic protein MsyB -
LQ200_RS20485 4253866..4254270 - 405 WP_000843582.1 DUF2541 family protein -
LQ200_RS20490 4254646..4256562 + 1917 WP_000516135.1 molecular chaperone DnaK -
LQ200_RS20495 4256651..4257781 + 1131 WP_001118464.1 molecular chaperone DnaJ -
LQ200_RS20500 4257885..4258037 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4258086..4258143 + 58 - - Antitoxin
LQ200_RS20505 4258623..4259789 + 1167 WP_000681352.1 Na+/H+ antiporter NhaA -
LQ200_RS20510 4259855..4260754 + 900 WP_001300855.1 transcriptional activator NhaR -
LQ200_RS20515 4260792..4261751 - 960 WP_000871677.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T296557 WP_000809168.1 NZ_OX030728:c4258037-4257885 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT296557 NZ_OX030728:4258086-4258143 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References