Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2711899..2712698 Replicon chromosome
Accession NZ_OX030728
Organism Escherichia coli isolate 68

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag LQ200_RS13200 Protein ID WP_000347273.1
Coordinates 2712234..2712698 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag LQ200_RS13195 Protein ID WP_001309780.1
Coordinates 2711899..2712234 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ200_RS13180 (2707684) 2707684..2708454 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
LQ200_RS13185 (2708470) 2708470..2709804 - 1335 WP_000599654.1 galactarate/glucarate/glycerate transporter GarP -
LQ200_RS13190 (2710179) 2710179..2711750 + 1572 WP_181261139.1 galactarate dehydratase -
LQ200_RS13195 (2711899) 2711899..2712234 + 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ200_RS13200 (2712234) 2712234..2712698 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ200_RS13205 (2712753) 2712753..2713562 - 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
LQ200_RS13210 (2713811) 2713811..2715091 + 1281 WP_000681959.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ200_RS13215 (2715114) 2715114..2715587 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ200_RS13220 (2715598) 2715598..2716377 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ200_RS13225 (2716367) 2716367..2717245 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ200_RS13230 (2717263) 2717263..2717697 + 435 WP_000948818.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2702536..2712698 10162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T296551 WP_000347273.1 NZ_OX030728:2712234-2712698 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT296551 WP_001309780.1 NZ_OX030728:2711899-2712234 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References