296524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4141036..4141715 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag LQ128_RS19955 Protein ID WP_000057523.1
Coordinates 4141036..4141338 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag LQ128_RS19960 Protein ID WP_000806442.1
Coordinates 4141374..4141715 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS19930 (4136412) 4136412..4138064 + 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
LQ128_RS19935 (4138102) 4138102..4138605 - 504 WP_000667000.1 hypothetical protein -
LQ128_RS19940 (4138602) 4138602..4139402 - 801 WP_000439798.1 hypothetical protein -
LQ128_RS19945 (4139426) 4139426..4139905 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
LQ128_RS19950 (4140109) 4140109..4140903 - 795 WP_000365147.1 TraB/GumN family protein -
LQ128_RS19955 (4141036) 4141036..4141338 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ128_RS19960 (4141374) 4141374..4141715 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
LQ128_RS19965 (4141773) 4141773..4144277 - 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
LQ128_RS19970 (4144539) 4144539..4145471 + 933 WP_000883041.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T296524 WP_000057523.1 NZ_OX030701:4141036-4141338 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT296524 WP_000806442.1 NZ_OX030701:4141374-4141715 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References