296516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2892026..2892628 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag LQ128_RS14015 Protein ID WP_000897302.1
Coordinates 2892026..2892337 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ128_RS14020 Protein ID WP_000356397.1
Coordinates 2892338..2892628 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS13990 (2887940) 2887940..2888539 + 600 WP_001296610.1 glucose-1-phosphatase -
LQ128_RS13995 (2888533) 2888533..2889405 + 873 WP_000920762.1 virulence factor BrkB family protein -
LQ128_RS14000 (2889402) 2889402..2889839 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
LQ128_RS14005 (2889884) 2889884..2890825 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ128_RS14010 (2890889) 2890889..2891797 - 909 WP_001385591.1 alpha/beta hydrolase -
LQ128_RS14015 (2892026) 2892026..2892337 + 312 WP_000897302.1 hypothetical protein Toxin
LQ128_RS14020 (2892338) 2892338..2892628 + 291 WP_000356397.1 NadS family protein Antitoxin
LQ128_RS14025 (2892987) 2892987..2893265 + 279 WP_001296612.1 hypothetical protein -
LQ128_RS14030 (2893662) 2893662..2893880 + 219 WP_001251293.1 CopG family transcriptional regulator -
LQ128_RS14035 (2894065) 2894065..2894805 - 741 WP_000608806.1 hypothetical protein -
LQ128_RS14040 (2894830) 2894830..2895678 - 849 WP_001038650.1 hypothetical protein -
LQ128_RS14045 (2895968) 2895968..2896210 + 243 WP_001068514.1 CopG family transcriptional regulator -
LQ128_RS14050 (2896392) 2896392..2897321 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T296516 WP_000897302.1 NZ_OX030701:2892026-2892337 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT296516 WP_000356397.1 NZ_OX030701:2892338-2892628 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References