Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2080578..2081377 Replicon chromosome
Accession NZ_OX030701
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag LQ128_RS10050 Protein ID WP_000347251.1
Coordinates 2080913..2081377 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag LQ128_RS10045 Protein ID WP_001296435.1
Coordinates 2080578..2080913 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ128_RS10030 (2076363) 2076363..2077133 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
LQ128_RS10035 (2077149) 2077149..2078483 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ128_RS10040 (2078858) 2078858..2080429 + 1572 WP_001273763.1 galactarate dehydratase -
LQ128_RS10045 (2080578) 2080578..2080913 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ128_RS10050 (2080913) 2080913..2081377 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ128_RS10055 (2081432) 2081432..2082241 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ128_RS10060 (2082490) 2082490..2083770 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ128_RS10065 (2083793) 2083793..2084266 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ128_RS10070 (2084277) 2084277..2085056 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ128_RS10075 (2085046) 2085046..2085924 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ128_RS10080 (2085942) 2085942..2086376 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T296514 WP_000347251.1 NZ_OX030701:2080913-2081377 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT296514 WP_001296435.1 NZ_OX030701:2080578-2080913 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References