Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1120534..1121180 Replicon chromosome
Accession NZ_OW970560
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag LQV17_RS05585 Protein ID WP_032433636.1
Coordinates 1120833..1121180 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag LQV17_RS05580 Protein ID WP_019725405.1
Coordinates 1120534..1120833 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV17_RS05560 (1116637) 1116637..1117977 + 1341 WP_023158721.1 glucarate dehydratase -
LQV17_RS05565 (1118050) 1118050..1119189 + 1140 WP_032433495.1 glycerate kinase -
LQV17_RS05570 (1119347) 1119347..1120156 - 810 Protein_1093 response regulator -
LQV17_RS05575 (1120160) 1120160..1120471 + 312 Protein_1094 glycerol-3-phosphate dehydrogenase C-terminal domain-containing protein -
LQV17_RS05580 (1120534) 1120534..1120833 - 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
LQV17_RS05585 (1120833) 1120833..1121180 - 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV17_RS05590 (1121356) 1121356..1123803 - 2448 WP_032433638.1 glycogen phosphorylase -
LQV17_RS05595 (1123821) 1123821..1125254 - 1434 WP_032433640.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T296489 WP_032433636.1 NZ_OW970560:c1121180-1120833 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT296489 WP_019725405.1 NZ_OW970560:c1120833-1120534 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References