Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356941..357587 Replicon chromosome
Accession NZ_OW970530
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag LQV07_RS01635 Protein ID WP_032433636.1
Coordinates 356941..357288 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag LQV07_RS01640 Protein ID WP_019725405.1
Coordinates 357288..357587 (+) Length 100 a.a.

Genomic Context


LQV07_RS01625LQV07_RS01630LQV07_RS01635LQV07_RS01640LQV07_RS01650LQV07_RS01655LQV07_RS01660LQV07_RS01645
Location: 352867..354300 (1434 bp)
Type: Others
Protein ID: WP_032433640.1
Location: 354318..356765 (2448 bp)
Type: Others
Protein ID: WP_032433638.1
Location: 356941..357288 (348 bp)
Type: Toxin
Protein ID: WP_032433636.1
Location: 357288..357587 (300 bp)
Type: Antitoxin
Protein ID: WP_019725405.1
Location: 359363..359692 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Location: 359743..360573 (831 bp)
Type: Others
Protein ID: WP_004151408.1
Location: 360623..361381 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Location: 357650..359158 (1509 bp)
Type: Others
Protein ID: WP_029602548.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LQV07_RS01625 (352867)352867..354300+1434WP_032433640.1glycogen synthase GlgA-
LQV07_RS01630 (354318)354318..356765+2448WP_032433638.1glycogen phosphorylase-
LQV07_RS01635 (356941)356941..357288+348WP_032433636.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LQV07_RS01640 (357288)357288..357587+300WP_019725405.1XRE family transcriptional regulatorAntitoxin
LQV07_RS01645 (357650)357650..359158-1509WP_029602548.1glycerol-3-phosphate dehydrogenase-
LQV07_RS01650 (359363)359363..359692+330WP_002920552.1thiosulfate sulfurtransferase GlpE-
LQV07_RS01655 (359743)359743..360573+831WP_004151408.1rhomboid family intramembrane serine protease GlpG-
LQV07_RS01660 (360623)360623..361381+759WP_002920548.1DeoR/GlpR family transcriptional regulator-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(31-84)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T296435 WP_032433636.1 NZ_OW970530:356941-357288 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp


Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT296435 WP_019725405.1 NZ_OW970530:357288-357587 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4S7KZ03


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4S7L580

References