Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2677266..2677789 Replicon chromosome
Accession NC_021670
Organism Staphylococcus aureus Bmb9393

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SABB_RS13875 Protein ID WP_000074048.1
Coordinates 2677266..2677532 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SABB_RS13880 Protein ID WP_000587616.1
Coordinates 2677532..2677789 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABB_RS13855 2672576..2673760 - 1185 WP_031890832.1 MFS transporter -
SABB_RS13860 2674156..2674932 - 777 WP_020444793.1 iron export ABC transporter permease subunit FetB -
SABB_RS13865 2674925..2675587 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
SABB_RS13870 2675835..2676911 - 1077 WP_020444794.1 M42 family metallopeptidase -
SABB_RS13875 2677266..2677532 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SABB_RS13880 2677532..2677789 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SABB_RS13885 2677895..2678089 - 195 WP_001790145.1 hypothetical protein -
SABB_RS13890 2678148..2678603 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SABB_RS13895 2678771..2680357 - 1587 WP_020444795.1 FMN-binding glutamate synthase family protein -
SABB_RS13900 2680552..2681301 + 750 WP_000072442.1 hypothetical protein -
SABB_RS13905 2681525..2682719 - 1195 Protein_2649 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T29639 WP_000074048.1 NC_021670:c2677532-2677266 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T29639 NC_021670:c2677532-2677266 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT29639 WP_000587616.1 NC_021670:c2677789-2677532 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT29639 NC_021670:c2677789-2677532 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References