Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356817..357463 Replicon chromosome
Accession NZ_OW970436
Organism Klebsiella pneumoniae isolate 147

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag LQV41_RS01635 Protein ID WP_032433636.1
Coordinates 356817..357164 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag LQV41_RS01640 Protein ID WP_019725405.1
Coordinates 357164..357463 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV41_RS01625 (352743) 352743..354176 + 1434 WP_032433640.1 glycogen synthase GlgA -
LQV41_RS01630 (354194) 354194..356641 + 2448 WP_032433638.1 glycogen phosphorylase -
LQV41_RS01635 (356817) 356817..357164 + 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV41_RS01640 (357164) 357164..357463 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
LQV41_RS01645 (357526) 357526..359034 - 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
LQV41_RS01650 (359239) 359239..359568 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LQV41_RS01655 (359619) 359619..360449 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LQV41_RS01660 (360499) 360499..361257 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T296321 WP_032433636.1 NZ_OW970436:356817-357164 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT296321 WP_019725405.1 NZ_OW970436:357164-357463 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References