Detailed information of TA system TA029626

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2173977..2174276
• Replicon: chromosome
• Accession: NC_021670
• Organism: Staphylococcus aureus Bmb9393

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SABB_RS15970
• Protein ID: WP_072482930.1
• Coordinates: 2174100..2174276 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2173977..2174032 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABB_RS11055	2169311..2169571	+	261	WP_001791826.1	hypothetical protein	-
SABB_RS11060	2169624..2169974	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SABB_RS11065	2170656..2171105	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SABB_RS16460	2171200..2171535	-	336	Protein_2115	SH3 domain-containing protein	-
SABB_RS11075	2172185..2172676	-	492	WP_000919350.1	staphylokinase	-
SABB_RS11080	2172867..2173622	-	756	WP_000861038.1	CHAP domain-containing protein	-
SABB_RS11085	2173634..2173888	-	255	WP_000611512.1	phage holin	-
SABB_RS11090	2173940..2174047	+	108	Protein_2119	hypothetical protein	-
-	2173969..2174108	+	140	NuclAT_0	-	-
-	2173969..2174108	+	140	NuclAT_0	-	-
-	2173969..2174108	+	140	NuclAT_0	-	-
-	2173969..2174108	+	140	NuclAT_0	-	-
-	2173977..2174032	+	56	-	-	Antitoxin
SABB_RS15970	2174100..2174276	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SABB_RS11100	2174426..2174722	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SABB_RS11105	2174780..2175067	-	288	WP_001040261.1	hypothetical protein	-
SABB_RS11110	2175114..2175266	-	153	WP_001153681.1	hypothetical protein	-
SABB_RS11115	2175256..2179041	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2169624..2224754	55130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T29626 WP_072482930.1 NC_021670:c2174276-2174100 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29626 NC_021670:c2174276-2174100 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT29626 NC_021670:2173977-2174032 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin