296235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 190314..191035 Replicon plasmid P1
Accession NZ_OW970316
Organism Pantoea agglomerans strain DAPP-PG734

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8J2A8
Locus tag OOS96_RS21540 Protein ID WP_010247063.1
Coordinates 190314..190625 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OOS96_RS21545 Protein ID WP_031590724.1
Coordinates 190622..191035 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS96_RS21530 (DAPPPG734_21845) 187017..188309 - 1293 WP_010247061.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -
OOS96_RS21535 (DAPPPG734_21850) 188320..189873 - 1554 WP_031590725.1 aspartate aminotransferase family protein -
OOS96_RS21540 (DAPPPG734_21855) 190314..190625 + 312 WP_010247063.1 type II toxin-antitoxin system HigB family toxin Toxin
OOS96_RS21545 (DAPPPG734_21860) 190622..191035 + 414 WP_031590724.1 helix-turn-helix domain-containing protein Antitoxin
OOS96_RS21550 (DAPPPG734_21865) 191151..192524 - 1374 WP_031590723.1 PTS ascorbate transporter subunit IIC -
OOS96_RS21555 (DAPPPG734_21870) 192564..192836 - 273 WP_031590722.1 PTS sugar transporter subunit IIB -
OOS96_RS21560 (DAPPPG734_21875) 192885..193334 - 450 WP_031590721.1 PTS sugar transporter subunit IIA -
OOS96_RS21565 (DAPPPG734_21880) 193911..194645 + 735 WP_031590720.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..530328 530328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12207.12 Da        Isoelectric Point: 9.8340

>T296235 WP_010247063.1 NZ_OW970316:190314-190625 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATPDALKIRFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKYRESKE

Download         Length: 312 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15420.44 Da        Isoelectric Point: 4.9795

>AT296235 WP_031590724.1 NZ_OW970316:190622-191035 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAMPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References