Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4012448..4013045 Replicon chromosome
Accession NZ_OW969912
Organism Klebsiella variicola isolate 0

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag LQ196_RS19535 Protein ID WP_012542526.1
Coordinates 4012728..4013045 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ196_RS19530 Protein ID WP_012542525.1
Coordinates 4012448..4012735 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ196_RS19500 (AN2340V1_3745) 4008358..4008606 + 249 WP_008805539.1 DUF1158 domain-containing protein -
LQ196_RS19505 (AN2340V1_3746) 4008623..4008964 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LQ196_RS19510 (AN2340V1_3747) 4008995..4010110 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
LQ196_RS19515 (AN2340V1_3748) 4010290..4010871 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
LQ196_RS19520 (AN2340V1_3749) 4010871..4011239 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
LQ196_RS19525 (AN2340V1_3750) 4011359..4012012 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
LQ196_RS19530 (AN2340V1_3751) 4012448..4012735 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
LQ196_RS19535 (AN2340V1_3752) 4012728..4013045 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ196_RS19540 (AN2340V1_3753) 4013230..4014273 - 1044 WP_230138674.1 DUF2157 domain-containing protein -
LQ196_RS19545 (AN2340V1_3755) 4014803..4015669 - 867 WP_022065427.1 helix-turn-helix transcriptional regulator -
LQ196_RS19550 (AN2340V1_3756) 4015778..4017205 + 1428 WP_016160435.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T296224 WP_012542526.1 NZ_OW969912:c4013045-4012728 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT296224 WP_012542525.1 NZ_OW969912:c4012735-4012448 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References