Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 40128..40776 Replicon chromosome
Accession NZ_OW969904
Organism Citrobacter freundii isolate 0

Toxin (Protein)


Gene name higB Uniprot ID A0A0D7M266
Locus tag LQ142_RS00185 Protein ID WP_016151211.1
Coordinates 40128..40490 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B5QFP8
Locus tag LQ142_RS00190 Protein ID WP_003844470.1
Coordinates 40477..40776 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ142_RS00170 (36587) 36587..37915 + 1329 WP_003023927.1 MFS transporter -
LQ142_RS00175 (38058) 38058..39449 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
LQ142_RS00180 (39575) 39575..40027 + 453 WP_003023933.1 DUF1198 family protein -
LQ142_RS00185 (40128) 40128..40490 + 363 WP_016151211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ142_RS00190 (40477) 40477..40776 + 300 WP_003844470.1 XRE family transcriptional regulator Antitoxin
LQ142_RS00195 (40895) 40895..42085 + 1191 WP_032937137.1 purine ribonucleoside efflux pump NepI -
LQ142_RS00200 (42135) 42135..43517 - 1383 WP_205688238.1 glycoside hydrolase family 1 protein -
LQ142_RS00205 (43612) 43612..43905 - 294 WP_003840665.1 YicS family protein -
LQ142_RS00210 (44036) 44036..44452 + 417 WP_003023951.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13788.66 Da        Isoelectric Point: 5.1976

>T296192 WP_016151211.1 NZ_OW969904:40128-40490 [Citrobacter freundii]
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11032.85 Da        Isoelectric Point: 8.5047

>AT296192 WP_003844470.1 NZ_OW969904:40477-40776 [Citrobacter freundii]
MATLKELMAKQSPESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQSDNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7M266

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5QFP8

References