Detailed information of TA system TA029619

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1676166..1676745
• Replicon: chromosome
• Accession: NC_021670
• Organism: Staphylococcus aureus Bmb9393

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SABB_RS08360
• Protein ID: WP_001025401.1
• Coordinates: 1676500..1676745 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1676166..1676531 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABB_RS08320	1672909..1673466	-	558	WP_000645042.1	DUF2815 family protein	-
SABB_RS08325	1673492..1674658	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SABB_RS08330	1674655..1675017	-	363	WP_000985984.1	hypothetical protein	-
SABB_RS08335	1675032..1675355	-	324	WP_000175001.1	hypothetical protein	-
SABB_RS08340	1675434..1675595	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SABB_RS08345	1675608..1675871	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SABB_RS08350	1675896..1676111	-	216	WP_001097552.1	hypothetical protein	-
SABB_RS08355	1676166..1676531	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SABB_RS08360	1676500..1676745	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SABB_RS08365	1676801..1677010	+	210	WP_000642492.1	hypothetical protein	-
SABB_RS08370	1677000..1677143	-	144	WP_000939498.1	hypothetical protein	-
SABB_RS08375	1677172..1677948	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SABB_RS08380	1677962..1678198	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SABB_RS08385	1678350..1678664	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SABB_RS08390	1678677..1679138	+	462	WP_000525004.1	hypothetical protein	-
SABB_RS08395	1679156..1679740	+	585	WP_000825948.1	hypothetical protein	-
SABB_RS08400	1679970..1680116	+	147	WP_001013104.1	hypothetical protein	-
SABB_RS08405	1680113..1680727	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1641586..1699689	58103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T29619 WP_001025401.1 NC_021670:c1676745-1676500 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T29619 NC_021670:c1676745-1676500 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT29619 NC_021670:1676166-1676531 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin