296167

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2770186..2770920 Replicon chromosome
Accession NZ_OW969691
Organism Citrobacter koseri isolate 0

Toxin (Protein)


Gene name higB Uniprot ID A8AI82
Locus tag LQV22_RS13310 Protein ID WP_012132927.1
Coordinates 2770615..2770920 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A8AI81
Locus tag LQV22_RS13305 Protein ID WP_012132926.1
Coordinates 2770186..2770527 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV22_RS13280 (2765671) 2765671..2766294 - 624 WP_112002282.1 DsbA family protein -
LQV22_RS13285 (2766291) 2766291..2768177 - 1887 WP_112002283.1 protein-disulfide reductase DsbD family protein -
LQV22_RS13290 (2768226) 2768226..2768591 - 366 WP_047457658.1 hypothetical protein -
LQV22_RS13295 (2768821) 2768821..2769741 + 921 WP_047457661.1 curved DNA-binding protein -
LQV22_RS13300 (2769741) 2769741..2770046 + 306 WP_112002284.1 chaperone modulator CbpM -
LQV22_RS13305 (2770186) 2770186..2770527 - 342 WP_012132926.1 HigA family addiction module antitoxin Antitoxin
LQV22_RS13310 (2770615) 2770615..2770920 - 306 WP_012132927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV22_RS13315 (2771157) 2771157..2772263 + 1107 WP_112002286.1 4Fe-4S binding protein -
LQV22_RS13320 (2772297) 2772297..2773073 - 777 WP_230032155.1 ABC transporter ATP-binding protein -
LQV22_RS13325 (2773073) 2773073..2773843 - 771 WP_058668982.1 ABC transporter permease -
LQV22_RS13330 (2773840) 2773840..2774847 - 1008 WP_049009338.1 ABC transporter substrate-binding protein -
LQV22_RS13335 (2774876) 2774876..2775595 - 720 WP_012132933.1 aspartate/glutamate racemase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11972.70 Da        Isoelectric Point: 8.3565

>T296167 WP_012132927.1 NZ_OW969691:c2770920-2770615 [Citrobacter koseri]
MPKKLVSIEDFRDQWLDDFFMYSAPHKKIPPDIHSALARKLDIINAAVSYKDLKSPPGNRYEELEGKLQEYSSIRVNKQY
RLIFKWVNGKAQDLYLDPHEY

Download         Length: 306 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13062.91 Da        Isoelectric Point: 5.1864

>AT296167 WP_012132926.1 NZ_OW969691:c2770527-2770186 [Citrobacter koseri]
MNQATRKPTTVGDILLYEYLEPLDLKINDLAEMLQVHRNTASALVNNNRKLTTDMAFRLSKVFDTSVEFWMNLQTAVDVW
ETENNARLQVEMSRVITASDFLAERQKQEKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A8AI82

Antitoxin

Source ID Structure
AlphaFold DB A8AI81

References