Detailed information of TA system TA296103

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 28306..28718
• Replicon: plasmid P1
• Accession: NZ_OW968329
• Organism: Enterobacter cloacae isolate 1382

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: LQ108_RS23390
• Protein ID: WP_223200913.1
• Coordinates: 28596..28718 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	28306..28491 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ108_RS23355 (24013)	24013..24534	+	522	WP_000290794.1	single-stranded DNA-binding protein	-
LQ108_RS23360 (24590)	24590..24823	+	234	WP_000005971.1	DUF905 domain-containing protein	-
LQ108_RS23365 (24884)	24884..26833	+	1950	WP_000109422.1	ParB/RepB/Spo0J family partition protein	-
LQ108_RS23370 (26888)	26888..27322	+	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
LQ108_RS23375 (27319)	27319..28038	+	720	WP_000116349.1	plasmid SOS inhibition protein A	-
LQ108_RS23380 (28035)	28035..28349	+	315	WP_000872086.1	hypothetical protein	-
- (28306)	28306..28491	+	186	NuclAT_0	-	Antitoxin
- (28306)	28306..28491	+	186	NuclAT_0	-	Antitoxin
- (28306)	28306..28491	+	186	NuclAT_0	-	Antitoxin
- (28306)	28306..28491	+	186	NuclAT_0	-	Antitoxin
LQ108_RS23385 (28499)	28499..28651	+	153	Protein_36	DUF5431 family protein	-
LQ108_RS23390 (28596)	28596..28718	+	123	WP_223200913.1	Hok/Gef family protein	Toxin
LQ108_RS23395 (29019)	29019..29268	-	250	Protein_38	hypothetical protein	-
LQ108_RS23400 (29564)	29564..29887	+	324	WP_000533253.1	hypothetical protein	-
LQ108_RS23405 (29946)	29946..30188	+	243	WP_000540588.1	hypothetical protein	-
LQ108_RS23410 (30454)	30454..30744	+	291	WP_073972341.1	hypothetical protein	-
LQ108_RS23415 (31215)	31215..31511	+	297	WP_001272251.1	hypothetical protein	-
LQ108_RS23420 (31621)	31621..32442	+	822	WP_001234445.1	DUF932 domain-containing protein	-
LQ108_RS23425 (32739)	32739..33341	-	603	WP_077761845.1	transglycosylase SLT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..72965	72965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-35)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4538.38 Da
• Isoelectric Point: 8.2691

>T296103 WP_223200913.1 NZ_OW968329:28596-28718 [Enterobacter cloacae]
IVCCTLLIFTLLTRNRLCEVRLKDGYREVTATMAYESGGK

Nucleotide

• Length: 123 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT296103 NZ_OW968329:28306-28491 [Enterobacter cloacae]
CCCGTGAACTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGGATATGAGCTATGATGTG
CCCGGCGCTTGAGGCTTTTTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGCAGAAAGCCCCGT
AGTTAATTTTCATTAACCCACGAGGC

Structures

Antitoxin