Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1138448..1139097 Replicon chromosome
Accession NZ_OW968328
Organism Enterobacter cloacae isolate 1382

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQ108_RS05355 Protein ID WP_230134505.1
Coordinates 1138735..1139097 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5E1A3P3
Locus tag LQ108_RS05350 Protein ID WP_013097693.1
Coordinates 1138448..1138747 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ108_RS05340 (AI2999V1_1037) 1134860..1136833 + 1974 WP_230134501.1 PhoX family phosphatase -
LQ108_RS05345 (AI2999V1_1038) 1136936..1138324 + 1389 WP_230134503.1 phenylalanine transporter -
LQ108_RS05350 (AI2999V1_1039) 1138448..1138747 - 300 WP_013097693.1 helix-turn-helix transcriptional regulator Antitoxin
LQ108_RS05355 (AI2999V1_1040) 1138735..1139097 - 363 WP_230134505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ108_RS05360 (AI2999V1_1041) 1139303..1140541 + 1239 WP_230134507.1 MFS transporter -
LQ108_RS05365 (AI2999V1_1042) 1140557..1141582 + 1026 WP_205918994.1 sugar phosphate isomerase/epimerase -
LQ108_RS05370 (AI2999V1_1043) 1141575..1142717 + 1143 WP_029882611.1 Gfo/Idh/MocA family oxidoreductase -
LQ108_RS05375 (AI2999V1_1044) 1142793..1143764 + 972 WP_218656501.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13959.99 Da        Isoelectric Point: 7.3235

>T296093 WP_230134505.1 NZ_OW968328:c1139097-1138735 [Enterobacter cloacae]
MWNVETTDRFDEWFLEQTTALKEDVLAAMHILSEFGPQLGRPFVDTVKASAFGNMKELRIQHRGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYKEMIALADVEYHRHLANKEAIWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10875.62 Da        Isoelectric Point: 8.6152

>AT296093 WP_013097693.1 NZ_OW968328:c1138747-1138448 [Enterobacter cloacae]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GELSIDVTLPNGKRIAFEI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1A3P3

References