Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3791917..3792458 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag LQ134_RS18485 Protein ID WP_000615983.1
Coordinates 3792180..3792458 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag LQ134_RS18480 Protein ID WP_000729703.1
Coordinates 3791917..3792177 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS18460 (3787592) 3787592..3788377 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
LQ134_RS18465 (3788349) 3788349..3790061 + 1713 Protein_3634 flagellar biosynthesis protein FlhA -
LQ134_RS18470 (3790285) 3790285..3790782 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
LQ134_RS18475 (3790958) 3790958..3791707 - 750 WP_000056849.1 C40 family peptidase -
LQ134_RS18480 (3791917) 3791917..3792177 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LQ134_RS18485 (3792180) 3792180..3792458 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LQ134_RS18490 (3792614) 3792614..3793354 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LQ134_RS18495 (3793325) 3793325..3794092 - 768 WP_000333380.1 class II glutamine amidotransferase -
LQ134_RS18500 (3794298) 3794298..3794876 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T296073 WP_000615983.1 NZ_OW968288:3792180-3792458 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT296073 WP_000729703.1 NZ_OW968288:3791917-3792177 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References