Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 714959..715652 Replicon chromosome
Accession NZ_OW968288
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LQ134_RS03485 Protein ID WP_000415584.1
Coordinates 714959..715255 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LQ134_RS03490 Protein ID WP_000650107.1
Coordinates 715257..715652 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ134_RS03450 (710047) 710047..710361 - 315 WP_000958598.1 putative quinol monooxygenase -
LQ134_RS03455 (710392) 710392..710973 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LQ134_RS03460 (711292) 711292..711624 + 333 WP_000917685.1 DUF2645 family protein -
LQ134_RS03465 (711670) 711670..713019 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LQ134_RS03470 (713016) 713016..713675 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LQ134_RS03475 (713827) 713827..714219 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LQ134_RS03480 (714272) 714272..714754 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LQ134_RS03485 (714959) 714959..715255 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LQ134_RS03490 (715257) 715257..715652 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LQ134_RS03495 (715785) 715785..717392 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LQ134_RS03500 (717530) 717530..719788 + 2259 WP_025693397.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T296060 WP_000415584.1 NZ_OW968288:714959-715255 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT296060 WP_000650107.1 NZ_OW968288:715257-715652 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References