296035

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3602133..3602932 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag LQ166_RS17725 Protein ID WP_000347251.1
Coordinates 3602133..3602597 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag LQ166_RS17730 Protein ID WP_001296435.1
Coordinates 3602597..3602932 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS17695 (3597134) 3597134..3597568 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ166_RS17700 (3597586) 3597586..3598464 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ166_RS17705 (3598454) 3598454..3599233 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ166_RS17710 (3599244) 3599244..3599717 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ166_RS17715 (3599740) 3599740..3601020 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ166_RS17720 (3601269) 3601269..3602078 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ166_RS17725 (3602133) 3602133..3602597 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ166_RS17730 (3602597) 3602597..3602932 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ166_RS17735 (3603081) 3603081..3604652 - 1572 WP_001273763.1 galactarate dehydratase -
LQ166_RS17740 (3605027) 3605027..3606361 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
LQ166_RS17745 (3606377) 3606377..3607147 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T296035 WP_000347251.1 NZ_OW968277:c3602597-3602133 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT296035 WP_001296435.1 NZ_OW968277:c3602932-3602597 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References