Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2791652..2792254 Replicon chromosome
Accession NZ_OW968277
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag LQ166_RS13770 Protein ID WP_000897302.1
Coordinates 2791943..2792254 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ166_RS13765 Protein ID WP_000356397.1
Coordinates 2791652..2791942 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ166_RS13735 (2786959) 2786959..2787888 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
LQ166_RS13740 (2788070) 2788070..2788312 - 243 WP_001068514.1 CopG family transcriptional regulator -
LQ166_RS13745 (2788602) 2788602..2789450 + 849 WP_001038650.1 hypothetical protein -
LQ166_RS13750 (2789475) 2789475..2790215 + 741 WP_000608806.1 hypothetical protein -
LQ166_RS13755 (2790400) 2790400..2790618 - 219 WP_001251293.1 CopG family transcriptional regulator -
LQ166_RS13760 (2791015) 2791015..2791293 - 279 WP_001296612.1 hypothetical protein -
LQ166_RS13765 (2791652) 2791652..2791942 - 291 WP_000356397.1 NadS family protein Antitoxin
LQ166_RS13770 (2791943) 2791943..2792254 - 312 WP_000897302.1 hypothetical protein Toxin
LQ166_RS13775 (2792483) 2792483..2793391 + 909 WP_001385591.1 alpha/beta hydrolase -
LQ166_RS13780 (2793455) 2793455..2794396 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ166_RS13785 (2794441) 2794441..2794878 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
LQ166_RS13790 (2794875) 2794875..2795747 - 873 WP_000920762.1 virulence factor BrkB family protein -
LQ166_RS13795 (2795741) 2795741..2796340 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T296033 WP_000897302.1 NZ_OW968277:c2792254-2791943 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT296033 WP_000356397.1 NZ_OW968277:c2791942-2791652 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References