Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3767287..3767828 Replicon chromosome
Accession NZ_OW968124
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag LQ159_RS18365 Protein ID WP_000615983.1
Coordinates 3767550..3767828 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag LQ159_RS18360 Protein ID WP_000729703.1
Coordinates 3767287..3767547 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ159_RS18340 (3762962) 3762962..3763747 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
LQ159_RS18345 (3763719) 3763719..3765431 + 1713 Protein_3609 flagellar biosynthesis protein FlhA -
LQ159_RS18350 (3765655) 3765655..3766152 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
LQ159_RS18355 (3766328) 3766328..3767077 - 750 WP_000056849.1 C40 family peptidase -
LQ159_RS18360 (3767287) 3767287..3767547 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LQ159_RS18365 (3767550) 3767550..3767828 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LQ159_RS18370 (3767984) 3767984..3768724 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LQ159_RS18375 (3768695) 3768695..3769462 - 768 WP_000333380.1 class II glutamine amidotransferase -
LQ159_RS18380 (3769668) 3769668..3770246 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3761090..3776370 15280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T296001 WP_000615983.1 NZ_OW968124:3767550-3767828 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT296001 WP_000729703.1 NZ_OW968124:3767287-3767547 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References