Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4578029..4578631 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LQ120_RS22130 Protein ID WP_000897305.1
Coordinates 4578320..4578631 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ120_RS22125 Protein ID WP_000356397.1
Coordinates 4578029..4578319 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS22100 (4573955) 4573955..4574857 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LQ120_RS22105 (4574854) 4574854..4575489 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LQ120_RS22110 (4575486) 4575486..4576415 + 930 WP_001749031.1 formate dehydrogenase accessory protein FdhE -
LQ120_RS22115 (4576745) 4576745..4576987 - 243 WP_001086388.1 protein YiiF -
LQ120_RS22120 (4577206) 4577206..4577424 - 219 WP_001295676.1 CopG family transcriptional regulator -
LQ120_RS22125 (4578029) 4578029..4578319 - 291 WP_000356397.1 NadS family protein Antitoxin
LQ120_RS22130 (4578320) 4578320..4578631 - 312 WP_000897305.1 hypothetical protein Toxin
LQ120_RS22135 (4578860) 4578860..4579768 + 909 WP_001162704.1 alpha/beta hydrolase -
LQ120_RS22140 (4579832) 4579832..4580773 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
LQ120_RS22145 (4580818) 4580818..4581255 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LQ120_RS22150 (4581252) 4581252..4582124 - 873 WP_000920762.1 virulence factor BrkB family protein -
LQ120_RS22155 (4582118) 4582118..4582717 - 600 WP_001295269.1 glucose-1-phosphatase -
LQ120_RS22160 (4582816) 4582816..4583601 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T295978 WP_000897305.1 NZ_OW968111:c4578631-4578320 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295978 WP_000356397.1 NZ_OW968111:c4578319-4578029 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References