Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3741880..3742421 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag LQ120_RS18320 Protein ID WP_000615982.1
Coordinates 3742143..3742421 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag LQ120_RS18315 Protein ID WP_000729704.1
Coordinates 3741880..3742140 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS18290 (3737663) 3737663..3738448 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
LQ120_RS18295 (3738420) 3738420..3740132 + 1713 Protein_3588 flagellar biosynthesis protein FlhA -
LQ120_RS18300 (3740237) 3740237..3740515 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
LQ120_RS18305 (3740508) 3740508..3740864 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
LQ120_RS18310 (3740921) 3740921..3741694 - 774 WP_000543899.1 C40 family peptidase -
LQ120_RS18315 (3741880) 3741880..3742140 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LQ120_RS18320 (3742143) 3742143..3742421 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LQ120_RS18325 (3742577) 3742577..3743317 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LQ120_RS18330 (3743288) 3743288..3744055 - 768 WP_000333380.1 class II glutamine amidotransferase -
LQ120_RS18335 (3744261) 3744261..3744839 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T295976 WP_000615982.1 NZ_OW968111:3742143-3742421 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT295976 WP_000729704.1 NZ_OW968111:3741880-3742140 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References