Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 589613..590412 Replicon chromosome
Accession NZ_OW968111
Organism Escherichia coli isolate 602

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag LQ120_RS02880 Protein ID WP_000347267.1
Coordinates 589613..590077 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LQ120_RS02885 Protein ID WP_001307405.1
Coordinates 590077..590412 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ120_RS02850 (584614) 584614..585048 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LQ120_RS02855 (585066) 585066..585944 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ120_RS02860 (585934) 585934..586713 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ120_RS02865 (586724) 586724..587197 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ120_RS02870 (587220) 587220..588500 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ120_RS02875 (588749) 588749..589558 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ120_RS02880 (589613) 589613..590077 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ120_RS02885 (590077) 590077..590412 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ120_RS02890 (590561) 590561..592132 - 1572 WP_001273741.1 galactarate dehydratase -
LQ120_RS02895 (592507) 592507..593841 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LQ120_RS02900 (593857) 593857..594627 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T295963 WP_000347267.1 NZ_OW968111:c590077-589613 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT295963 WP_001307405.1 NZ_OW968111:c590412-590077 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References