295954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3154459..3155061 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LQ149_RS15195 Protein ID WP_000897305.1
Coordinates 3154459..3154770 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ149_RS15200 Protein ID WP_000356397.1
Coordinates 3154771..3155061 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS15165 (3149489) 3149489..3150274 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
LQ149_RS15170 (3150373) 3150373..3150972 + 600 WP_001295269.1 glucose-1-phosphatase -
LQ149_RS15175 (3150966) 3150966..3151838 + 873 WP_000920762.1 virulence factor BrkB family protein -
LQ149_RS15180 (3151835) 3151835..3152272 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LQ149_RS15185 (3152317) 3152317..3153258 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ149_RS15190 (3153322) 3153322..3154230 - 909 WP_001162704.1 alpha/beta hydrolase -
LQ149_RS15195 (3154459) 3154459..3154770 + 312 WP_000897305.1 hypothetical protein Toxin
LQ149_RS15200 (3154771) 3154771..3155061 + 291 WP_000356397.1 NadS family protein Antitoxin
LQ149_RS15205 (3155666) 3155666..3155884 + 219 WP_001315930.1 CopG family transcriptional regulator -
LQ149_RS15210 (3156104) 3156104..3156346 + 243 WP_001087409.1 protein YiiF -
LQ149_RS15215 (3156676) 3156676..3157605 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
LQ149_RS15220 (3157602) 3157602..3158237 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LQ149_RS15225 (3158234) 3158234..3159136 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T295954 WP_000897305.1 NZ_OW968011:3154459-3154770 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295954 WP_000356397.1 NZ_OW968011:3154771-3155061 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References