Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2341422..2342221 Replicon chromosome
Accession NZ_OW968011
Organism Escherichia coli isolate 58

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag LQ149_RS11230 Protein ID WP_000347266.1
Coordinates 2341757..2342221 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LQ149_RS11225 Protein ID WP_001307405.1
Coordinates 2341422..2341757 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ149_RS11210 (2337207) 2337207..2337977 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
LQ149_RS11215 (2337993) 2337993..2339327 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LQ149_RS11220 (2339702) 2339702..2341273 + 1572 WP_001273741.1 galactarate dehydratase -
LQ149_RS11225 (2341422) 2341422..2341757 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LQ149_RS11230 (2341757) 2341757..2342221 + 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LQ149_RS11235 (2342276) 2342276..2343085 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LQ149_RS11240 (2343334) 2343334..2344614 + 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
LQ149_RS11245 (2344637) 2344637..2345110 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LQ149_RS11250 (2345121) 2345121..2345900 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LQ149_RS11255 (2345890) 2345890..2346768 + 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
LQ149_RS11260 (2346786) 2346786..2347220 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2330773..2342221 11448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T295951 WP_000347266.1 NZ_OW968011:2341757-2342221 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT295951 WP_001307405.1 NZ_OW968011:2341422-2341757 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References