Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3759419..3759960 Replicon chromosome
Accession NZ_OW967975
Organism Escherichia coli isolate 10

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag LQ150_RS18300 Protein ID WP_000615983.1
Coordinates 3759682..3759960 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag LQ150_RS18295 Protein ID WP_000729703.1
Coordinates 3759419..3759679 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ150_RS18275 (3755094) 3755094..3755879 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
LQ150_RS18280 (3755851) 3755851..3757563 + 1713 Protein_3596 flagellar biosynthesis protein FlhA -
LQ150_RS18285 (3757787) 3757787..3758284 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
LQ150_RS18290 (3758460) 3758460..3759209 - 750 WP_000056849.1 C40 family peptidase -
LQ150_RS18295 (3759419) 3759419..3759679 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LQ150_RS18300 (3759682) 3759682..3759960 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LQ150_RS18305 (3760116) 3760116..3760856 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LQ150_RS18310 (3760827) 3760827..3761594 - 768 WP_000333380.1 class II glutamine amidotransferase -
LQ150_RS18315 (3761800) 3761800..3762378 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3753222..3768502 15280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T295916 WP_000615983.1 NZ_OW967975:3759682-3759960 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT295916 WP_000729703.1 NZ_OW967975:3759419-3759679 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References