Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4880215..4880817 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LQ127_RS23850 Protein ID WP_000897305.1
Coordinates 4880506..4880817 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ127_RS23845 Protein ID WP_000356397.1
Coordinates 4880215..4880505 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS23825 (4876717) 4876717..4877619 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LQ127_RS23830 (4877616) 4877616..4878251 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LQ127_RS23835 (4878248) 4878248..4879177 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
LQ127_RS23840 (4879392) 4879392..4879610 - 219 WP_001298592.1 CopG family transcriptional regulator -
LQ127_RS23845 (4880215) 4880215..4880505 - 291 WP_000356397.1 NadS family protein Antitoxin
LQ127_RS23850 (4880506) 4880506..4880817 - 312 WP_000897305.1 hypothetical protein Toxin
LQ127_RS23855 (4881046) 4881046..4881954 + 909 WP_001318161.1 alpha/beta hydrolase -
LQ127_RS23860 (4882018) 4882018..4882959 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LQ127_RS23865 (4883004) 4883004..4883441 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LQ127_RS23870 (4883438) 4883438..4884310 - 873 WP_000920762.1 virulence factor BrkB family protein -
LQ127_RS23875 (4884304) 4884304..4884903 - 600 WP_001314324.1 glucose-1-phosphatase -
LQ127_RS23880 (4885002) 4885002..4885787 - 786 WP_000059679.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T295898 WP_000897305.1 NZ_OW967966:c4880817-4880506 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT295898 WP_000356397.1 NZ_OW967966:c4880505-4880215 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References